{"id":25,"date":"2023-03-30T12:23:20","date_gmt":"2023-03-30T12:23:20","guid":{"rendered":"https:\/\/people.socsci.tau.ac.il\/mu\/ybh\/research\/"},"modified":"2024-04-13T05:51:26","modified_gmt":"2024-04-13T05:51:26","slug":"research","status":"publish","type":"page","link":"https:\/\/people.socsci.tau.ac.il\/mu\/ybh\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\n \n
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Research<\/b>\n <\/h2>\n <\/div>\n <\/section>\n
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Our\nresearch is focused on stress-related disorders including posttraumatic stress\ndisorder (PTSD), anxiety disorders, and depression. We apply experimental\nparadigms, neuroimaging techniques, randomized controlled trials, and a\ncognitive-developmental-neuroscience approach to explore biological, cognitive,\nand behavioral aspects of these psychopathologies. We use the knowledge gained\nthrough basic research to develop new strategies for diagnosis, prevention, and\ntreatment of these disorders in children, adolescents, and adults.<\/p>\n <\/div>\n <\/section>\n

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Understanding the Nature of Biased Cognition in\nPsychopathology<\/b>\n <\/h2>\n
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A normative function of the mechanisms underlying fear is to\nfacilitate detection and processing of danger in the environment and to help\nthe organism respond effectively to threatening situations. Biases in\nprocessing threat-related information have been implicated in the etiology and\nmaintenance of anxiety and stress-related disorders. In our research we explore\nquestions such as:
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  • Do biases in threat\nmonitoring and processing play a causal or maintaining roles in stress-related\npsychopathology? <\/li>\n
  • What are the neural\nmechanisms associated with cognitive biases in individuals who suffer from stress-related\npsychopathologies, such as anxiety, PTSD, and depression? <\/li>\n
  • What are the effects of\nacute stress and trauma on threat processing? <\/li>\n <\/ul>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n
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    Sample publications<\/b>\n <\/h2>\n

    Bar-Haim, Y., Lamy, D., Pergamin, L., Bakermans-Kranenburg,\nM. J., & van IJzendoorn, M. H. (2007). Threat-related attentional bias\nin anxious and non-anxious individuals: A meta-analytic study<\/b>. Psychological\nBulletin<\/i>, 133<\/i>, 1-24. 
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    Bar-Haim, Y., Holoshitz, Y., Eldar, S., Frenkel, T.I.,\nMuller, D., Charney, D.S., Pine, D.S., Fox, N.A., & Wald, I. (2010). Life-threatening\ndanger suppresses attention bias to threat<\/b>. American Journal of Psychiatry<\/i>, 167<\/i>, 694-698. 
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    Naim, R., Abend, R. Wald, I., Eldar, S., Levi, O., Fruchter,\nE., Ginat, K., Halpern, P., Sipos, M. L., Adler, A.B., Bliese, P. D., Quartana,\nP. J., Pine, D. S., & Bar-Haim, Y. (2015). Threat-related attention bias\nvariability and post-traumatic stress<\/b>. American Journal of\nPsychiatry<\/i>, 172<\/i>, 1242-1250. 
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    Wald, I., Degnan, K.A., Gorodetsky, E., Charney, D.S., Fox,\nN.A., Fruchter, E., Goldman, D., Lubin, G., Pine, D.S., Bar-Haim, Y. (2013). Attention\nto threats and combat-related post-traumatic stress symptoms: Prospective\nassociations and moderation by the serotonin transporter gene<\/b>. JAMA\nPsychiatry<\/i>, 70<\/i>, 401-408. 
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    Abend, R., Pine, D. S., Fox, N. A., & Bar-Haim, Y.\n(2014). Learning and memory consolidation processes of attention bias modification\nin anxious and non-anxious individuals<\/b>. Clinical Psychological Science<\/i>, 2<\/i>, 620-627. 
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    Lazarov, A., Abend, R., & Bar-Haim, Y. (2016). Social\nanxiety is related to increased dwell time on socially threatening faces<\/b>. Journal\nof Affective Disorders<\/i>, 193<\/i>, 282-288.   \n <\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/section>\n

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    Understanding the Nature of Intrusive Re-experiencing in\nPTSD<\/b>\n <\/h2>\n
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    Despite being introduced\nnearly four decades ago, disputes remain regarding the definition and core\nsymptoms of PTSD. In other areas of psychopathology research, a focus on core\nsymptom dimensions has provided a foundation for basic and clinical research to\novercome disagreements on categorical syndrome definitions. We apply a\ndomain-focused approach to PTSD research, focusing on the unique symptom domain\nof intrusive and involuntary recollection and re-experiencing of trauma memories.\nBy emphasizing this core dimension, we implement mechanisms-oriented\ninvestigations and apply concrete strategies for improving posttraumatic psychopathology\ntreatment.
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    Sample publications<\/b>\n <\/h2>\n

    Herz, N., Bar-Haim, Y., Holmes, E.A., and Censor, N. (2020). Intrusive memories: a mechanistic signature for emotional memory persistence<\/b>. Behaviour Research and Therapy<\/i>, 135<\/i>, 103752.
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    Bar-Haim, Y., Stein, M.B., Bryant, R.A., Bliese, P.D., Ben\nYehuda, A., Kringelbach, M.L., Jain, S., Dan, O., Lazarov, A., Wald, I., Levi,\nO., Neria, Y., and Pine, D.S. (2021). Intrusive traumatic re-experiencing:\nPathognomonic of the psychological response to traumatic stress<\/b>. American Journal of Psychiatry<\/i>, 178<\/i>, 119-122. 
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    Herz, N., Bar-Haim, Y., Tavor, I., Tik, N., Sharon, H.,\nHolmes, E.A., & Censor, N., (2022). Neuromodulation of visual cortex\nreduces the intensity of intrusive memories<\/b>. Cerebral Cortex<\/i>, 32<\/i>,\n408\u2013417. 
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    Levi, O., Ben Yehuda, A., Pine, D.S., & Bar-Haim, Y.\n(2022). A sobering look at treatment effectiveness of military-related\npost-traumatic stress disorder<\/b>. Clinical Psychological Science<\/i>, 10<\/i>,\n690-699.   \n <\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/section>\n

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    Developing Methods of Modifying Cognitive Biases and\nReducing Clinical Symptoms<\/b>\n <\/h2>\n
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    Cognitive bias modification (CBM) is a class of mechanized\npsychological interventions designed to target specific aberrant cognitive\nprocesses considered key in the etiology and\/or maintenance of specific psychiatric\ndisorders. Our lab is engaged in a multistage translational process that involves:\n(1) Identification of reliable cognitive targets and establishing their\nassociation with specific disorders; (2) Clinical translations designed to\nrectify the identified cognitive targets; (3) Verification of effective target\nengagement; and (4) Testing of clinical utility in randomized controlled\ntrials.
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    Sample publications<\/b>\n <\/h2>\n

    Badura-Brack, A.S., Naim, R., Ryan, T.J., Levy, O., Abend,\nR., Khanna, M.M., McDermott, T.J., Pine, D.S., & Bar-Haim, Y. (2015). Effect\nof attention training on attention bias variability and PTSD symptoms:\nRandomized controlled trials in Israeli and US combat veterans<\/b>. American\nJournal of Psychiatry<\/i>, 172<\/i>, 1233-1241. 
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    Wald, I., Fruchter, E., Ginat, K., Stolin, E., Dagan, D.,\nBliese, P.D., Quartana, P.J., Sipos, M.L., Pine, D.S., & Bar-Haim Y.\n(2016). Selective prevention of combat-related PTSD using attention bias\nmodification training: A randomized controlled trial<\/b>. Psychological\nMedicine<\/i>, 46<\/i>, 2627-2636. 
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    Lazarov, A., Pine, D.S., & Bar-Haim, Y. (2017). Gaze-contingent\nmusic reward treatment for social anxiety disorder: A randomized controlled\ntrial<\/b>. American Journal of Psychiatry<\/i>, 174<\/i>,\n649-656. 
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    Arad, G., Azriel, O., Pine, D.S., Lazarov, A., Sol, O.,\nWeiser, M., Garber, E., Bloch, M., & Bar-Haim, Y. (2023). Attention\nbias modification treatment (ABM) vs a selective serotonin reuptake inhibitor\n(SSRI) and waitlist control for social anxiety disorder: A randomized clinical\ntrial<\/b>. American Journal of Psychiatry, 1<\/i>80, <\/i>\n 357-366<\/span>.   \n <\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/section>\n \n \n \n \n \n","protected":false},"excerpt":{"rendered":"

    Research Our research is focused on stress-related disorders including posttraumatic stress disorder (PTSD), anxiety disorders, and depression. We apply experimental paradigms, neuroimaging techniques, randomized controlled trials, and a cognitive-developmental-neuroscience approach to explore biological, cognitive, and behavioral aspects of these psychopathologies. We use the knowledge gained through basic research to develop new strategies for diagnosis, prevention, … Continue reading “Research”<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-25","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/people.socsci.tau.ac.il\/mu\/ybh\/wp-json\/wp\/v2\/pages\/25","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/people.socsci.tau.ac.il\/mu\/ybh\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/people.socsci.tau.ac.il\/mu\/ybh\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/people.socsci.tau.ac.il\/mu\/ybh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/people.socsci.tau.ac.il\/mu\/ybh\/wp-json\/wp\/v2\/comments?post=25"}],"version-history":[{"count":7,"href":"https:\/\/people.socsci.tau.ac.il\/mu\/ybh\/wp-json\/wp\/v2\/pages\/25\/revisions"}],"predecessor-version":[{"id":569,"href":"https:\/\/people.socsci.tau.ac.il\/mu\/ybh\/wp-json\/wp\/v2\/pages\/25\/revisions\/569"}],"wp:attachment":[{"href":"https:\/\/people.socsci.tau.ac.il\/mu\/ybh\/wp-json\/wp\/v2\/media?parent=25"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}