Goal-directed behavior involves a continuous loop of perceptions and actions, and integration of multiple cognitive process. For example, the simple act of opening a door requires the representation of an intention (do I want to exit the room or allow someone in), action-selection (should I use my palm or rather my elbow to avoid possible COVID infection?), and perception (for successful control of the limb with respect to the door-handle). With respect to motor control, these processes are non-trivial since there is no one-to-one mapping between actions and outcome, and this relationship is highly dependent on context. For example, when the car gear is set to reverse, the same action of pressing the gas paddle (and corresponding motor commands) has completely different consequences. In my lab, we use neuroimaging (fMRI/EEG), VR and various behavioral measures to explore how the brain generates voluntary movement and purposeful behavior.
News
We are exited to announce our upcoming Multisensory Integration in Action workshop, coming up this December in Israel!
For more information and registration:
http://motorcognition2022.wixsite.com/workshop
Our symposium on action representation in Regensburg, Germany has ended! We would like to thank all of our wonderful speakers, poster presenters and participants for the success of this symposium!
http://actionrepresentation.wixsite.com/minerva2022
Latest Publications:
Same Action, Different Meaning: Neural Substrates of Action Semantic Meaning – Aberbach-Goodman, S., Buaron, B., Mudrik, L. & Mukamel, R., Cerebral Cortex, 2022
Real-time processes in the development of action planning – Ossmy, O., Kaplan, B.E., Han, D., Xu, M., Bianco, C., Mukamel, R. & Adolph, K.E., Current Biology, 2022
Children do not distinguish efficient from inefficient actions during observation – Ossmy, O., Han, D., Kaplan, B.E., Xu, M., Bianco, C., Mukamel, R. & Adolph, K.E., Scientifc Reports 2021
Our Lab in the News:
English:
Prof. Roy Mukamel receives the Kadar Family Award for Outstanding Research at Tel Aviv University
3D Virtual Reality Therapy Could Help Repair Damaged Limbs- ‘NoCamels’, Feb 2017
Scientists harness virtual reality to teach damaged limbs new tricks- ‘Haaretz’, Dec 2016
New study reveals your left hand DOES know what your right is doing- Sunday Express, Dec 2016
Hebrew:
How actions and their sensory consequences are represented in the human brain- ISF, July 2019
Prof. Roy Mukamel receives the Kadar Family Award for Outstanding Research
Improvement of motor abilities using virtual reality- ‘Haaretz’, Dec 2016
Improvement of motor abilities using virtual reality- Ynet, Dec 2016
Improvement of motor abilities using virtual reality- ‘Mabat’, Dec 2016
Improvement of motor abilities using virtual reality- Weizmann institute of science, Dec 2016
Insight from Inside: Intracranial studies of the human brain conference (30.11-1.12.2016)
Lab Members
Roy Mukamel
Principal Investigator
Shiri Koren
Lab Manager
Shlomit Ben Ami
Research Fellow
Batel Buaron
PhD student
Shahar Aberbach-Goodman
PhD student
Uri Peled
M.A. Student
Guy Baratz
MSc Student
Jonathan Sahar
MSc Student
Ori Yaron
Research Assistant
Alumni
Ori Ossmy, PhD
Alumnus
Roee Gilron, PhD
Alumnus
Shiri Simon, PhD
Alumnus
Daniel Reznik, PhD
Alumnus
Matan Mazor, MSc
Alumnus
Anastasia Shuster, PhD
Alumnus
Nadav Aridan, MSc
Alumnus
Ariel Krasovsky, MSc
Alumnus
Roni Maimon, MSc
Alumnus
Daniel Shechter, M.A
Alumnus
Lihi Sadeh, M.A.
Alumnus
Bat El Even, M.A.
Alumnus
Roni Mazinter, M.A.
Alumnus
Hadar Dery, M.A.
Alumnus
Publications
2022
Same Action, Different Meaning: Neural Substrates of Action Semantic Meaning – Aberbach-Goodman, S., Buaron, B., Mudrik, L. & Mukamel, R., Cerebral Cortex, 2022
Real-time processes in the development of action planning – Ossmy, O., Kaplan, B.E., Han, D., Xu, M., Bianco, C., Mukamel, R. & Adolph, K.E., Current Biology, 2022
2021
Children do not distinguish efficient from inefficient actions during observation – Ossmy, O., Han, D., Kaplan, B.E., Xu, M., Bianco, C., Mukamel, R. & Adolph, K.E., Scientifc Reports 2021
Action-locked neural responses in auditory cortex to self-generated sounds – Reznik, D., Guttman, N., Buaron, B., Zion-Golumbic, E. & Mukamel, R., Cerebral Cortex 2021
2020
Single-cell activity in human STG during perception of phonemes is organized according to manner of articulation – Lakertz, Y., Ossmy, O., Friedmann, N., Mukamel, R. & Fried, I., NeuroImage 2020
Motor learning in hemi-Parkinson using VR-manipulated sensory feedback – Ossmy O., Mansano L., Frenkel-Toledo S., Kagan E., Koren S., Gilron R., Reznik D., Soroker S. & Mukamel R., Disability and Rehabilitation 2020
Voluntary actions modulate perception and neural representation of action-consequences in a hand-dependent manner– Buaron B., Reznik D., Gilron R., Mukamel R., Cerebral Cortex 2020
2019
Better-than-chance classification for signal detection– Rosenblatt, J. D., Benjamini, Y., Gilron, R., Mukamel, R., & Goeman, J. J., Biostatistics, 2019
Motor output, neural states and auditory perception– Reznik, D. & Mukamel, R., Neuroscience & Biobehavioral Reviews, 2019
2018
A novel tool for time-locking study plans to results– Mazor, M., Mazor, N. & Mukamel, R., European Journal of Neuroscience, 2018
Predicted sensory consequences of voluntary actions modulate amplitude of preceding readiness potentials– Reznik, D., Simon, S. & Mukamel, R., Neuropsychologia, 2018
Suppression of EEG Mu Rhythm During Action Observation Corresponds with Subsequent Changes in Behavior– Aridan, N., Ossmy, O., Buaron, B., Reznik, D. & Mukamel, R., Brain Research, 2018
Perception as a Route for Motor Skill Learning: Perspectives from Neuroscience– Ossmy, O. & Mukamel, R., Neuroscience, 2018
Behavioral and Neural Effects of Congruency of Visual Feedback During Short-Term Motor Learning– Ossmy, O. & Mukamel, R., NeuroImage, 2018
2017
Using Virtual Reality to Transfer Motor Skill Knowledge from One Hand to Another– Ossmy, O. & Mukamel, R., J. Vis. Exp., 2017
Sensitivity to perception level differentiates two subnetworks within the mirror neuron system– Simon, S. & Mukamel, R., SCAN 2017
What’s in a pattern? Examining the type of signal multivariate analysis uncovers at the group level– Gilron, R., Rosenblatt, J., Koyejo, O., Poldrack, R.A. & Mukamel, R., NeuroImage 2017
Short Term Motor-Skill Acquisition Improves with Size of Self-Controlled Virtual Hands– Ossmy, O. & Mukamel, R., Plos One 2017
2016
Neural Network Underlying Intermanual Skill Transfer in Humans– Ossmy, O. & Mukamel, R., Cell Reports 2016
Activity in primary motor cortex during action observation covaries with subsequent behavioral changes in execution– Aridan, N. & Mukamel, R., Brain and Behavior 2016
Activity in superior parietal cortex during training by observation predicts asymmetric learning levels across hands– Ossmy, O. & Mukamel, R., Scientific Reports 2016
Power modulation of electroencephalogram mu and beta frequency depends on perceived level of observed actions– Simon S. & Mukamel, R., Brain and Behavior 2016
2015
Decoding speech perception from single cell activity in humans– Ossmy, O., Fried, I. & Mukamel, R., NeuroImage 2015
Preconscious prediction of a driver’s decision using intracranial recordings– Perez, O., Mukamel, R., Tankus, A., Rosenblatt, J.D., Yeshurun, Y. & Fried, I., Journal of Cognitive Neuroscience 2015
Perceived loudness of self-generated sounds is differentially modified by expected sound intensity– Reznik, D., Henkin, Y., Levy, O. & Mukamel, R., Plos One 2015
Enhanced auditory evoked activity to self-generated sounds is mediated by primary and supplementary motor cortices– Reznik, D., Ossmy, O. & Mukamel, R., Journal of Neuroscience 2015
Invited Book Chapter
“Neural correlates of intentions” in “Human Agency: Functions and Mechanisms”– Gilron R., Simon S. & Mukamel R. Editors Eitam B. & Haggard P., Oxford University Press, 2015
2014
Differentiating intended sensory outcome from underlying motor actions in the human brain– Krasovsky, A., Gilron, R., Yeshurun, Y. & Mukamel, R., Journal of Neuroscience 2014
Decoding letter position in word reading– Ossmy, O., Ben-Shachar, M. & Mukamel, R., Cortex 2014
Lateralized enhancement of auditory cortex activity and increased sensitivity to self-generated sounds– Reznik, D., Henkin, Y., Schadel, N. & Mukamel, R., Nature Communications 2014
2012
Memory enhancement and deep-brain stimulation of the entorhinal area– Suthana, N., Haneef, Z., Stern, J., Mukamel, R., Behnke, E., Knowlton, B. & Fried, I., New England Journal of Medicine 2012
2011
Human intracranial recordings and cognitive neuroscience– Mukamel, R. & Fried, I., Annual Review of Psychology 2011
Invariance of firing rate and field potential dynamics to stimulus modulation rate in human auditory cortex– Mukamel, R., Nir, Y., Harel, M., Arieli, A., Malach, R. & Fried, I., Human Brain Mapping 2011
Internally generated preactivation of single neurons in human medial frontal cortex predicts volition– Fried, I., Mukamel, R. & Kreiman, G., Neuron 2011
2010
Single-neuron responses in humans during execution and observation of actions– Mukamel, R., Ekstrom, A.D., Kaplan, J., Iacoboni, M. & Fried, I., Current Biology 2010
A neural substrate in the human hippocampus for linking successive events– Paz, R., Gelbard-Sagiv, H., Mukamel, R., Harel, M., Malach, R. & Fried, I., PNAS 2010
2008
Internally generated reactivation of single neurons in human hippocampus during free recall– Gelbard-Sagiv, H., Mukamel, R., Harel, M., Malach, R. & Fried, I., Science 2008
Interhemispheric correlations of slow spontaneous neuronal fluctuations revealed in human sensory cortex– Nir, Y., Mukamel, R., Dinstein, I., Privman, E., Harel, M., Fisch, L., Gelbard-Sagiv, H., Kipervasser, S., Andelman, F., Neufeld, M.Y., Kramer, U., Arieli, A., Fried, I. & Malach, R., Nature Neuroscience 2008
Human single-neuron responses at the threshold of conscious recognition– Quiroga, R.Q., Mukamel, R., Isham, E.A., Malach, R. & Fried, I., PNAS 2008
Ultra-fine frequency tuning revealed in single neurons of human auditory cortex– Bitterman, Y., Mukamel, R., Malach, R., Fried, I. & Nelken, I., Nature 2008
2007
Coupling between neuronal firing rate, gamma LFP, and BOLD fMRI is related to interneuronal correlations– Nir, Y., Fisch, L., Mukamel, R., Gelbard-Sagiv, H., Arieli, A., Fried, I. & Malach, R., Current Biology 2007
Enhanced category tuning revealed by intracranial electroencephalograms in high-order human visual areas– Privman, E., Nir, Y., Kramer, U., Kipervasser, S., Andelman, F., Neufeld, M.Y., Mukamel, R., Yeshurun, Y., Fried, I. & Malach, R., Journal of Neuroscience 2007
2005
Coupling between neuronal firing, field potentials, and FMRI in human auditory cortex– Mukamel, R., Gelbard, H., Arieli, A., Hasson, U., Fried, I. & Malach, R., Science 2005
2004
Enhanced temporal non-linearities in human object-related occipito-temporal cortex– Mukamel, R., Harel, M., Hendler, T. & Malach, R., Cerebral Cortex 2004