Home

We study basic questions of human motor cognition at the behavioral and system neuroscience levels. Specific lines of research include: Motor skill learning, intentions and voluntary movements, how voluntary actions modulate perception, and self/other recognition from action consequences.

What are the principles (and neural mechanisms) underlying efficient learning of motor skills? What is the optimal sensory information relevant for learning? What training schedule yields optimal performance gains? How does the nervous system represent goals and sensory consequences of actions? how does it translate these goals into specific motor acts? What are the principles that determine which action to select over the others? What determines the timing of voluntary movements and what are the principles that govern its inhibition under different circumstances? We continually learn the contingencies between actions and their sensory consequences and modify our behavior to increase our ecological fitness in an appropriate manner. How are these contingencies learned and represented in the nervous system? How does our brain determine the causal link between our own actions and their consequences to correctly attribute agency (‘I did that’)? What is the role of the motor system in such recognition processes?

To address these and related questions we combine cutting edge technology with advanced neuroimaging and electrophysiological techniques. Insights obtained from healthy subjects are applied to clinical studies with patient populations with motor deficits (such as stroke). People in the lab have diverse backgrounds including electrical engineering, biology, psychology, computer science, and physics. This diversity allows us to address experimental questions at multiple levels in an interdisciplinary manner – from the cognitive, to the neural, computational, and methodological levels.

 

Lab Members

Roy Mukamel, PhD
Principal Investigator
rmukamel@post.tau.ac.ilCV
Shiri Koren
Lab Manager
shirikoren@mail.tau.ac.il
Batel Buaron
PhD student
batelbuaron@mail.tau.ac.ilCV
Shahar Aberbach
PhD student
shahara@mail.tau.ac.il
Bat El Even
M.A Student
bateleven@mail.tau.ac.il
Roni Mazinter
M.A Student
ronimazinter@mail.tau.ac.ilCV
Shalev Lavi
Research Assistant
shalevlavi@mail.tau.ac.il

Alumni

Ori Ossmy, PhD
Alumnus
oriossmy@gmail.comCV
Roee Gilron, PhD
Alumnus
roeegilron@gmail.comCV
Shiri Simon, PhD
Alumnus
shirisimon@post.tau.ac.ilCV
Daniel Reznik, PhD
Alumnus
reznikda@gmail.comCV
Matan Mazor, MSc
Alumnus
matanmazor@mail.tau.ac.ilCV
Anastasia Shuster, PhD
Alumnus
anastasiashu@gmail.comCV
Nadav Aridan, MSc
Alumnus
nadavari@mail.tau.ac.ilCV
Ariel Krasovsky, MSc
Alumnus
ariel.krasovsky@gmail.com
Roni Maimon, MSc
Alumnus
ronimaimon@gmail.com
Daniel Shechter, M.A
Alumnus
phyzmuz@gmail.com
Lihi Sadeh, M.A.
Alumnus
lihisadeh@mail.tau.ac.il

Publications

2019

Motor output, neural states and auditory perception– Reznik, D. & Mukamel, R., Neuroscience & Biobehavioral Reviews, 2019

2018

A novel tool for time-locking study plans to results– Mazor, M., Mazor, N. & Mukamel, R.,  European Journal of Neuroscience, 2018

Predicted sensory consequences of voluntary actions modulate amplitude of preceding readiness potentials– Reznik, D., Simon, S. & Mukamel, R., Neuropsychologia, 2018

Suppression of EEG Mu Rhythm During Action Observation Corresponds with Subsequent Changes in Behavior– Aridan, N., Ossmy, O., Buaron, B., Reznik, D. & Mukamel, R., Brain Research, 2018

Perception as a Route for Motor Skill Learning: Perspectives from Neuroscience– Ossmy, O. & Mukamel, R., Neuroscience, 2018

Behavioral and Neural Effects of Congruency of Visual Feedback During Short-Term Motor Learning– Ossmy, O. & Mukamel, R., NeuroImage, 2018

2017

Using Virtual Reality to Transfer Motor Skill Knowledge from One Hand to Another– Ossmy, O. & Mukamel, R.,  J. Vis. Exp., 2017

Sensitivity to perception level differentiates two subnetworks within the mirror neuron system– Simon, S. & Mukamel, R.,  SCAN 2017

What’s in a pattern? Examining the type of signal multivariate analysis uncovers at the group level– Gilron, R., Rosenblatt, J., Koyejo, O., Poldrack, R.A. & Mukamel, R., NeuroImage 2017

Short Term Motor-Skill Acquisition Improves with Size of Self-Controlled Virtual Hands– Ossmy, O. & Mukamel, R., Plos One 2017

2016

Neural Network Underlying Intermanual Skill Transfer in Humans– Ossmy, O. & Mukamel, R., Cell Reports 2016

Activity in primary motor cortex during action observation covaries with subsequent behavioral changes in execution– Aridan, N. & Mukamel, R.,  Brain and Behavior 2016

Activity in superior parietal cortex during training by observation predicts asymmetric learning levels across hands– Ossmy, O. & Mukamel, R., Scientific Reports 2016

Power modulation of electroencephalogram mu and beta frequency depends on perceived level of observed actions– Simon S. & Mukamel, R., Brain and Behavior 2016

2015

Decoding speech perception from single cell activity in humans– Ossmy, O., Fried, I. & Mukamel, R., NeuroImage 2015

Preconscious prediction of a driver’s decision using intracranial recordings– Perez, O., Mukamel, R., Tankus, A., Rosenblatt, J.D., Yeshurun, Y. & Fried, I., Journal of Cognitive Neuroscience 2015

Perceived loudness of self-generated sounds is differentially modified by expected sound intensity– Reznik, D., Henkin, Y., Levy, O. & Mukamel, R., Plos One 2015

Enhanced auditory evoked activity to self-generated sounds is mediated by primary and supplementary motor cortices– Reznik, D., Ossmy, O. & Mukamel, R., Journal of Neuroscience 2015

Invited Book Chapter

“Neural correlates of intentions” in “Human Agency: Functions and Mechanisms”– Gilron R., Simon S. & Mukamel R. Editors Eitam B. & Haggard P., Oxford University Press, 2015

2014

Differentiating intended sensory outcome from underlying motor actions in the human brain– Krasovsky, A., Gilron, R., Yeshurun, Y. & Mukamel, R., Journal of Neuroscience 2014

Decoding letter position in word reading– Ossmy, O., Ben-Shachar, M. & Mukamel, R., Cortex 2014

Lateralized enhancement of auditory cortex activity and increased sensitivity to self-generated sounds– Reznik, D., Henkin, Y., Schadel, N. & Mukamel, R., Nature Communications 2014

2012

Memory enhancement and deep-brain stimulation of the entorhinal area– Suthana, N., Haneef, Z., Stern, J., Mukamel, R., Behnke, E., Knowlton, B. & Fried, I., New England Journal of Medicine 2012

2011

Human intracranial recordings and cognitive neuroscience– Mukamel, R. & Fried, I., Annual Review of Psychology 2011

Invariance of firing rate and field potential dynamics to stimulus modulation rate in human auditory cortex– Mukamel, R., Nir, Y., Harel, M., Arieli, A., Malach, R. & Fried, I., Human Brain Mapping 2011

Internally generated preactivation of single neurons in human medial frontal cortex predicts volition– Fried, I., Mukamel, R. & Kreiman, G., Neuron 2011

2010

Single-neuron responses in humans during execution and observation of actions– Mukamel, R., Ekstrom, A.D., Kaplan, J., Iacoboni, M. & Fried, I., Current Biology 2010

A neural substrate in the human hippocampus for linking successive events– Paz, R., Gelbard-Sagiv, H., Mukamel, R., Harel, M., Malach, R. & Fried, I., PNAS 2010

2008

Internally generated reactivation of single neurons in human hippocampus during free recall– Gelbard-Sagiv, H., Mukamel, R., Harel, M., Malach, R. & Fried, I., Science 2008

Interhemispheric correlations of slow spontaneous neuronal fluctuations revealed in human sensory cortex– Nir, Y., Mukamel, R., Dinstein, I., Privman, E., Harel, M., Fisch, L., Gelbard-Sagiv, H., Kipervasser, S., Andelman, F., Neufeld, M.Y., Kramer, U., Arieli, A., Fried, I. & Malach, R., Nature Neuroscience 2008

Human single-neuron responses at the threshold of conscious recognition– Quiroga, R.Q., Mukamel, R., Isham, E.A., Malach, R. & Fried, I., PNAS 2008

Ultra-fine frequency tuning revealed in single neurons of human auditory cortex– Bitterman, Y., Mukamel, R., Malach, R., Fried, I. & Nelken, I., Nature 2008

2007

Coupling between neuronal firing rate, gamma LFP, and BOLD fMRI is related to interneuronal correlations– Nir, Y., Fisch, L., Mukamel, R., Gelbard-Sagiv, H., Arieli, A., Fried, I. & Malach, R., Current Biology 2007

Enhanced category tuning revealed by intracranial electroencephalograms in high-order human visual areas– Privman, E., Nir, Y., Kramer, U., Kipervasser, S., Andelman, F., Neufeld, M.Y., Mukamel, R., Yeshurun, Y., Fried, I. & Malach, R., Journal of Neuroscience 2007

2005

Coupling between neuronal firing, field potentials, and FMRI in human auditory cortex– Mukamel, R., Gelbard, H., Arieli, A., Hasson, U., Fried, I. & Malach, R., Science 2005

2004

Enhanced temporal non-linearities in human object-related occipito-temporal cortex– Mukamel, R., Harel, M., Hendler, T. & Malach, R., Cerebral Cortex 2004

Gallery

VIDEOS

art & brain week 2018- Prof. Roy mukamel

Prof. Roy Mukamel receives the Kadar Family Award for Outstanding Research at Tel Aviv University

Videos – Short Term Motor-Skill Acquisition Improves with Size of Self-Controlled Virtual Hands– Ossmy, O. & Mukamel, R., Plos One 2017

 

Videos – Neural Network Underlying Intermanual Skill Transfer in Humans– Ossmy, O. & Mukamel, R., Cell Reports 2016